The final report detailing the scientific workshop held to discuss issues related to the interpretation of thyroid disruption outcomes held in spring 2017 has been published by the European Commission. As part of this project, case studies were reviewed with the intention of elucidating several aspects and issues highlighted as important for understanding thyroid disruption. The topics discussed were:
A strategy for developing improved or novel endpoints important for detecting thyroid disruption could unfold at the following levels:
The workshop concluded that until these gaps are filled, it is necessary to evaluate substances on the basis of incomplete data regarding thyroid disruption. In this context, the finding of diminished serum thyroid hormone concentrations in animal studies should be taken as predictive of adverse effects in humans in the absence of substance-specific data.
It was noted that observations of thyroid disruption in rodent laboratory studies can be useful for the identification of thyroid disrupting properties in other wildlife mammalian species. Considering the preservation of the thyroid system across taxa, such data would also raise concerns for e.g. birds, fish or amphibians, although species-species extrapolations will not be straight-forward due to differences in exposure routes and other factors (e.g. the presence of a placenta in mammals).
The report can be found here:(https://publications.europa.eu/en/publication-detail/-/publication/472d2c88-a8b1-11e7-837e-01aa75ed71a1/language-en)
The outcome and conclusion of this workshop are likely to be included in updated EFSA guidance on endocrine disruption.
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