EFSA have published a report of the December 2015 expert workshop held to review the current TTC approach.  The experts concluded that the TTC approach is based on scientific risk assessment principles and fit for purpose as a screening tool, to assess low dose exposures and to identify those for which further data are necessary to assess the human health risk.  The current TTC database is considered to cover lifetime exposures only.  The expert group made recommendations to improve and expand the TTC concept, and proposed a tiered approach (revised decision tree), considering the current state-of-the art science and available toxicological databases.

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